刘古月，女，1986年2月生，辽宁省海城市人，药理学博士，制药工程系讲师。
E-mail: liuguyue5211314@163.com
教育背景:
09/2008–07/2013 攻读沈阳药科大学攻读药理学博士学位，师从景永奎教授。
09/2004 – 07/2008本科毕业于沈阳药科大学基础药学基地班。
研究方向：
天然产物、化合物及其新型衍生物的抗肿瘤活性与机制研究；
具有抗肿瘤活性的先导化合物的结构改造及构效关系分析；
有机合成方法学研究。
工作经历:
曾就职于山东绿叶制药有限公司，任药理研究员。期间负责完成和参与多项抗肿瘤新药的药效学和毒理学研究，完善药物筛选与评价技术体系，通过调研靶向制剂、小分子靶向药物和抗肿瘤抗体背景资料，理论上完善靶向制剂药物和抗体抗肿瘤药物的评价体系。后赴日本高知工科大学学习斑马鱼的饲养方法和建立斑马鱼研究模型。
发表论文:
Guyue Liu, Rui Wang, Yuetong Wang, Guisen Zhao, Linxiang Zhao, and Yongkui Jing.
Ethacrynic acidoxadiazoleanalogues induce apoptosis inhematological malignant cells through
down-regulation of Mcl-1 and c-FLIP which was attenuated by GSTP1-1.Mol Cancer Ther.
2013;12:1837-47.
Xinmei Yang,Guyue Liu, Hongcai Li, Yun Zhang, Dandan Song, Chunmin Li, Rui Wang, Bo
Liu, Wen Liang, Yongkui Jing and Guisen Zhao. Novel oxadiazole analogues derived from
ethacrynic acid: design, synthesis, and structure-activity relationships in inhibiting the activity of glutathione S-transferase P1-1 and cancer cell proliferation.J Med Chem. 2010;53:1015-22.
Ting Li,Guyue Liu, Hongcai Li, Xinmei Yang, Yongkui Jing, Guisen Zhao. The synthesis of
ethacrynic acid thiazole derivatives as glutathione S-transferase pi inhibitors.Bioorg Med Chem.
2012;20:2316-22.
Li P, Tan Y,Liu G, Liu Y, Liu J, Yin Y, Zhao G.Synthesis and biological evaluation of novel
indoline-2,3-dione derivatives as antitumor agents.DrugDiscov Ther.2014;8(3):110-6.
Dahong Li, Hao Cai, Lei Wang,Guyue Liu, Yuetong Wang, Lei Wang, Hequan Yao, Xiaoming
Wu, Yijun Sun, Jinyi Xu.Synthesis of spirolactone-type diterpenoid derivatives of oridonin with
improved antiproliferative effects in human hepatoma Bel-7402 cells.Euro J Med Chem.
2013;59:322-8.
Shengli Niu, Zhanlin Li, Feng Ji,Guyue Liu, Nan Zhao, Xiaoqiu Liu, Yongkui Jing, Huiming
Hua. Xanthones from the stem bark of Garcinia bracteata with growth inhibitory effects against
HL-60 cells.Phytochemistry. 2012;77:280-6.
Fengrong Li, Dongmei Zhao, Jinhong Ren, Feiyue Hao,Guyue Liu, Shengfei Jin, Yongkui Jing,
Maosheng Cheng. 2-(2-Methylfuran-3-carboxamido)-3-phenylpropanoic acid, a potential
CYP26A1 inhibitor to enhance all-trans retinoic acid-induced leukemia cell differentiation based
on virtual screening and biological evaluation.Bioorg Med Chem. 2013;21:3256-61.
Liu T, Zhang S, Zhu J,etcLiu G,Hua H.Two new amides from a halotolerant fungus,
Myrothecium sp. GS-17.J Antibiot (Tokyo).2015;68(4):267-70.
